I-O Optimise: a novel multinational real-world research platform in thoracic malignancies

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Ekman, Simon | Griesinger, Frank | Baas, Paul | Chao, David | Chouaid, Christos | O'Donnell, John, C | Penrod, John, R | Daumont, Melinda | Lacoin, Laure | Mckenney, Alexia | Khovratovich, Masha | Munro, Robin, Ej | Durand-Zaleski, Isabelle | Johnsen, Søren, Paaske

Edité par CCSD ; Future Medicine -

International audience. Aim: To describe I-O Optimise, a multinational program providing real-world insights into lung cancer management. Materials & methods: Real-world data source selection for I-O Optimise followed a structured approach focused on population coverage, key variable capture, continuous/consistent data availability, record duration and data latency, and database expertise. Results: As of 31 October 2018, seven real-world data sources were included in I-O Optimise, providing data on characteristics, treatment patterns and clinical outcomes from more than 45,000 patients/year with non-small-cell lung cancer, small-cell lung cancer and mesothelioma across Denmark, Norway, Portugal, Spain, Sweden and the UK. Conclusion: The ongoing I-O Optimise initiative has the potential to provide a broad, robust and dynamic research platform to continually address numerous research objectives in the lung cancer arena.

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