Afficher la couverture 'Vitamin A and retinoid signaling: genomic and nongenomic effects | Al Tanoury, Ziad' en grand format
/5

0 avis

Vitamin A and retinoid signaling: genomic and nongenomic effects

Archive ouverte

Al Tanoury, Ziad | Piskunov, Aleksandr | Rochette-Egly, Cécile

Edité par CCSD ; American Society for Biochemistry and Molecular Biology -

Vitamin A or retinol is arguably the most multifunctional vitamin in the human body, as it is essential from embryogenesis to adulthood. The pleiotropic effects of vitamin A are exerted mainly by one active metabolite, all-trans retinoic acid (atRA), which regulates the expression of a battery of target genes through several families of nuclear receptors (RARs, RXRs, and PPARbeta/delta), polymorphic retinoic acid (RA) response elements, and multiple coregulators. It also involves extranuclear and nontranscriptional effects, such as the activation of kinase cascades, which are integrated in the nucleus via the phosphorylation of several actors of RA signaling. However, vitamin A itself proved recently to be active and RARs to be present in the cytosol to regulate translation and cell plasticity. These new concepts expand the scope of the biologic functions of vitamin A and RA.

Consulter en ligne

Suggestions

Du même auteur

Nuclear and extra-nuclear effects of retinoid acid receptors: how they are interconnected

Archive ouverte | Piskunov, Aleksandr | CCSD

The nuclear retinoic acid receptors (RAR alpha, beta and gamma) and their isoforms are ligand-dependent regulators of transcription Transcription , which mediate the effects of all-trans retinoic acid (RA), the active endogenous m...

Genes involved in cell adhesion and signaling: a new repertoire of retinoic acid receptor target genes in mouse embryonic fibroblasts

Archive ouverte | Al Tanoury, Ziad | CCSD

Nuclear retinoic acid (RA) receptors (RARalpha, beta and gamma) are ligand-dependent transcription factors that regulate the expression of a battery of genes involved in cell differentiation and proliferation. They are also phosph...

Phosphorylation of the retinoic acid receptor RARgamma2 is crucial for the neuronal differentiation of mouse embryonic stem cells

Archive ouverte | Al Tanoury, Ziad | CCSD

Retinoic acid (RA) plays key roles in cell differentiation and growth arrest by activating nuclear RA receptors (RARs) (alpha, beta and gamma), which are ligand-dependent transcription factors. RARs are also phosphorylated in resp...

Chargement des enrichissements...