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Impact of nutritional factors on in vitro PK/PD modelling of polymyxin B against various strains of Acinetobacter baumannii

Archive ouverte | Lacroix, Mathilde | CCSD

International audience. The main objective of this study was to assess the effect of rich artificial cation-adjusted Mueller-Hinton broth (CAMHB) on the growth of three strains of Acinetobacter baumannii (ATCC 19606...

Transcriptomic data to support in vitro semimechanistic PK/PD modelling of Polymyxin B against Acinetobacter baumannii

Archive ouverte | Lacroix, Mathilde | CCSD

International audience. BackgroundTime-kill experiments (TK) with Acinetobacter baumannii and polymyxin B (PMB), usually show CFU decrease followed by regrowth even at concentrations up to 16xMIC, potentially due to...

In vitro PK/PD modelling of polymyxin B against resistant strain of A. baumannii in presence of mucin

Archive ouverte | Lacroix, Mathilde | CCSD

International audience. Pulmonary infections with Acinetobacter baumannii are often difficult to treat due to multidrug resistance. Furthermore, the presence of mucin (main component of mucus) in lung has been shown...

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