CXCR2 and CXCL4 regulate survival and self-renewal of hematopoietic stem/progenitor cells

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CXCR2 and CXCL4 regulate survival and self-renewal of hematopoietic stem/progenitor cells

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Edité par CCSD ; American Society of Hematology -

International audience. Key Points Chemokine ligands CXCL1-4, 6, 10, 11, and 13 are upregulated in human quiescent HSCs with CXCR2 and CXCL4 regulating their survival. Genetic ablation of Cxcr2 or Cxcl4 in murine models induces initial expansion but eventual exhaustion of HSC in transplantation assays.

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