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Temporally controlled targeted somatic mutagenesis in mouse eye pigment epithelium

Archive ouverte | Mori, Mikiro | CCSD

International audience. Abstract To generate temporally controlled site‐specific somatic mutations in the mouse eye pigment epithelium, we generated a TRP1‐Cre‐ER T2 transgenic mouse line that expresses the tamoxife...

Site-specific somatic mutagenesis in the retinal pigment epithelium

Archive ouverte | Mori, Mikiro | CCSD

International audience. PURPOSE: Generate site-specific somatic mutations selectively in the retinal pigment epithelium (RPE) in mice. METHODS: A transgenic mouse line expressing the Cre recombinase under the contro...

Cellular retinol-binding protein I is essential for vitamin A homeostasis

Archive ouverte | Ghyselinck, Norbert | CCSD

The gene encoding cellular retinol (ROL, vitA)-binding protein type I (CRBPI) has been inactivated. Mutant mice fed a vitA-enriched diet are healthy and fertile. They do not present any of the congenital abnormalities related to r...

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