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PREMISE: A database of 20 Macaca Fascicularis PET/MRI brain imaging available for research

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Chalet, Lucie | Debatisse, Justine | Wateau, Oceane | Boutelier, Timothe | Wiart, Marlène | Costes, Nicolas | Merida, Ines | Redouté, Jérôme | Langlois, Jean-Baptiste | Lancelot, Sophie | Léon, Christelle | Cho, Tae-Hee | Mechtouff, Laura | Eker, Omer Faruk | Nighoghossian, Norbert | Canet-Soulas, Emmanuelle | Becker, Guillaume

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Abstract Non-human primate (NHP) studies are unique in translational research, especially in neurosciences and neuroimaging approaches are a preferred method for scaling cross-species comparative neurosciences. In this regard, neuroimaging database development and sharing are encouraged to increase the number of subjects available to the community while limiting the number of animals used in research. We present here a simultaneous PET/MR dataset of 20 Macaca Fascicularis structured according to the Brain Imaging Data Structure (BIDS) standards. This database contains multiple MRI sequences (anatomical, diffusion and perfusion imaging notably), as well as PET perfusion and inflammation using respectively [ 15 O]H 2 O and [ 11 C]PK11195 radiotracers. We describe the pipeline method to assemble baseline data from various cohorts and qualitatively assessed all the data using signal-to-noise and contrast-to-noise ratios as well as the median of intensity. The database is stored and available through the PRIME-DE consortium repository.

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