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Hes1 and Hes5 as notch effectors in mammalian neuronal differentiation

Archive ouverte | Ohtsuka, Toshiyuki | CCSD

International audience. While the transmembrane protein Notch plays an important role in various aspects of development, and diseases including tumors and neurological disorders, the intracellular pathway of mammali...

Hes1 is a negative regulator of inner ear hair cell differentiation

Archive ouverte | Zheng, J. Lisa | CCSD

International audience. ABSTRACT Hair cell fate determination in the inner ear has been shown to be controlled by specific genes. Recent loss-of-function and gain-of-function experiments have demonstrated that Math1...

Basic helix-loop-helix transcription factors regulate the neuroendocrine differentiation of fetal mouse pulmonary epithelium

Archive ouverte | Ito, Takaaki | CCSD

International audience. ABSTRACT To clarify the mechanisms that regulate neuroendocrine differentiation of fetal lung epithelia, we have studied the expression of the mammalian homologs of achaete-scute complex (Mas...

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