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Basolateral targeting by leucine-rich repeat domains in epithelial cells

Archive ouverte | Legouis, Renaud | CCSD

International audience. The asymmetric distribution of proteins to basolateral and apical membranes is an important feature of epithelial cell polarity. To investigate how basolateral LAP proteins (LRR (for leucine-...

Two novel Drosophila TAF(II)s have homology with human TAF(II)30 and are differentially regulated during development

Archive ouverte | Georgieva, Sofia | CCSD

TFIID is a multiprotein complex composed of the TATA binding protein (TBP) and TBP-associated factors (TAF(II)s). The binding of TFIID to the promoter is the first step of RNA polymerase II preinitiation complex assembly on protei...

Mechanism of inhibition of the Drosophila and mammalian EGF receptors by the transmembrane protein Kekkon 1.

Archive ouverte | Ghiglione, Christian | CCSD

The transmembrane protein Kekkon 1 (Kek1) has previously been shown to act in a negative feedback loop to downregulate the Drosophila Epidermal Growth Factor Receptor (DER) during oogenesis. We show that this protein plays a simil...

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