Use of antibiotics for the treatment of immunoglobulin a nephropathy

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Lepage, Patricia | Monteiro, Renato | Mkaddem, Sanae Ben | Chemouny, Jonathan | Berthelot, Laureline | Gleeson, James

Edité par CCSD -

Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis worldwide. IgA is mainly produced by the gut associated lymphoid tissue (GALT). Both experimental and clinical data suggest a role of the gut microbiota in this disease. The inventors aimed to determine if an intervention targeting the gut microbiota could impact disease development in a humanized mouse model of IgAN, the α1KI-CD89TG mice. Four- week old mice were divided into two groups to receive either antibiotics or vehicle-control by oral gavage twice a week for eight weeks. Antibiotic treatment efficiently depleted the faecal microbiota, impaired GALT architecture and impacted mouse IgA production. However, while hlgA1 and mIgG serum levels were unchanged, the antibiotic treatment markedly prevented hlgA1 mesangial deposition, glomerular inflammation and the development of proteinuria. This was associated with a significant decrease in circulating hlgA1-mIgG complexes. These data support that use of antibiotics would be suitable for the treatment of immunoglobulin A nephropathy.

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