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Archive ouverte | Gilles, Arnaud | CCSD

International audience. The human 80S ribosome is the cellular nucleoprotein nanomachine in charge of protein synthesis that is profoundly affected during cancer transformation by oncogenic proteins and provides can...

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International audience. Recent advances in cryo electron microscopy (cryo-EM) and image processingprovide new opportunities to analyse drug targets at high resolution. However, structural heterogeneity limits resolu...

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Archive ouverte | Holvec, Samuel | CCSD

International audience. The ribosomal RNA of the human protein synthesis machinery comprises numerous chemical modifications that are introduced during ribosome biogenesis. Here we present the 1.9 A resolution cryo ...

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