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Implication of Dicer1 gene in ageing and age-related pathologies in mice. Implication du gène Dicer1 dans le vieillissement et ses pathologies chez la souris

Archive ouverte | de Cauwer, Aurore | CCSD

Despite a 30-year gain in life expectancy over the last century in developed countries, reaching old age remains associated with the development of chronic and/or disabling pathologies. Defining the actors of aging is therefore a ...

Measuring the transcriptome-wide effects of aging on murine adipocytes using RNAseq

Archive ouverte | de Cauwer, Aurore | CCSD

International audience. Adipose tissue plays a central role in age-related diseases. While RNAseq protocols exist for many tissues, few data have been generated with this technology to explore gene expression in adi...

DICER1: A Key Player in Rheumatoid Arthritis, at the Crossroads of Cellular Stress, Innate Immunity, and Chronic Inflammation in Aging

Archive ouverte | de Cauwer, Aurore | CCSD

International audience. FiGuRe 1 | Canonical and non-canonical functions of DICER1 in the nucleus and the cytosol. The canonical function of DICER1 leads to microRNA maturation in the cytoplasm. Others functions are...

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