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Human induced pluripotent stem cells ‐derived liver organoids grown on a Biomimesys® hyaluronic acid‐based hydroscaffold as a new model for studying human lipoprotein metabolism

Archive ouverte | Roudaut, Meryl | CCSD

International audience. Abstract The liver plays a key role in the metabolism of lipoproteins, controlling both production and catabolism. To accelerate the development of new lipid‐lowering therapies in humans, it ...

PCSK9 regulates the NODAL signaling pathway and cellular proliferation in hiPSCs

Archive ouverte | Roudaut, Meryl | CCSD

International audience. Proprotein convertase subtilisin kexin type 9 (PCSK9) is a key regulator of low-density lipoprotein (LDL) cholesterol metabolism and the target of lipid-lowering drugs. PCSK9 is mainly expres...

Generation of human induced pluripotent stem cell lines from four unrelated healthy control donors carrying European genetic background

Archive ouverte | Girardeau, Aurore | CCSD

International audience. Four human induced pluripotent stem cell (hiPSC) lines have been generated from healthy control European donors, and validated. This resource represents a useful tool for stem cell-based rese...

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