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Archive ouverte | Braun, Thorsten | CCSD

International audience. Abstract Background: Differentiation based therapy by all trans retinoic acid (ATRA) and arsenic trioxide (ATO) results in cure of >90% of patients with acute promyelocytic leukemia (APL)....

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Archive ouverte | Wu, Hsin-Chieh | CCSD

International audience. Abstract Acute myeloid leukemia (AML) pathogenesis often involves a mutation in the NPM1 nucleolar chaperone, but the bases for its transforming properties and overall association with favora...

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Archive ouverte | Pardieu, Bryann | CCSD

International audience. By querying metabolic pathways associated with leukemic stemness and survival in multiple AML datasets, we nominated SLC7A11 encoding the xCT cystine importer as a putative AML dependency. Ge...

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