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Revisiting the pro-oxidant activity of copper: interplay of ascorbate, cysteine, and glutathione

Archive ouverte | Falcone, Enrico | CCSD

Copper (Cu) is essential for most organisms, but it can be poisonous in excess, through mechanisms such as protein aggregation, trans-metallation, and oxidative stress. The latter could implicate the formation of potentially harmf...

A widespread family of ribosomal peptide metallophores involved in bacterial adaptation to metal stress

Archive ouverte | Leprevost, Laura | CCSD

International audience. Ribosomally synthesized and posttranslationally modified peptides (RiPPs) are a structurally diverse group of natural products that bacteria employ in their survival strategies. Herein, we ch...

Restoring cellular copper homeostasis in Alzheimer disease: a novel peptide shuttle is internalized by an ATP-dependent endocytosis pathway involving Rab5- and Rab14-endosomes

Archive ouverte | Okafor, Michael | CCSD

International audience. CPPs, or Cell-Penetrating Peptides, offer invaluable utility in disease treatment due to their ability to transport various therapeutic molecules across cellular membranes. Their unique chara...

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