Prehospital Lyophilized Plasma Transfusion for Trauma-Induced Coagulopathy in Patients at Risk for Hemorrhagic Shock
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Jost, Daniel | Lemoine, Sabine | Lemoine, Frédéric | Derkenne, Clément | Beaume, Sébastien | Lanoë, Vincent | Maurin, Olga | Louis-Delaurière, Emilie | Delacote, Maëlle | Dang-Minh, Pascal | Franchin-Frattini, Marilyn | Bihannic, René | Savary, Dominique | Levrat, Albrice | Baudouin, Clémence | Trichereau, Julie | Salomé, Marina | Frattini, Benoit | Ha, Vivien Hong Tuan | Jouffroy, Romain | Seguineau, Edouard | Titreville, Rudy | Roquet, Florian | Stibbe, Olivier | Vivien, Benoit | Verret, Catherine | Bignand, Michel | Travers, Stéphane | Martinaud, Christophe | Arock, Michel | Raux, Mathieu | Prunet, Bertrand | Ausset, Sylvain | Sailliol, Anne | Tourtier, Jean-Pierre | Albinni, Souha | Attias, Arié | Benchetritt, Deborah | Benichou, Laura | Boizat, Stéphane | Boutinaud, Philippe | Calinet, Alexandra | Camoin-Jau, Laurence | Cerro, Valérie | Cesareo, Eric | Chahir, Noureddine | Chassery, Carine | Chollet, Charlotte | Choubard, Anouk | Clavere, Gaëlle | Clavier, Benoit | Courtade, Henri | Creppy, Séverine | David, Jean-Stéphane | de Raucourt, Emmanuelle | Debord, Sophie | Delort, Josée | Deruaz-Cunsolo, Christine | Dettori, Isabelle | Dhers, Marion | Dias, Patricia | Diaz, Maxime | Dieuset, Sophie | Dubien, Pierre-Yves | Duchateau, François-Xavier | Duranteau, Jacques | Fiot, Charlotte | Flocard, Bernard | Foissaud, Vincent | Fournier, Marc | Francois, Anne | Gaget, Gilles | Garnier, Benjamin | Gaste, Jean-Louis | Grimault, Olivier | Gueugniaud, Pierre-Yves | Idir, Zakia | Burnichon, Jerome | Journois, Didier | Blanc-Jouvan, Florence | Kerbaul, Francois | Klein, Isabelle | Lafitte, Blandine | Langeron, Olivier | Lassale, Bernard | Lebouc, Marie | Lecarpentier, Eric | Lejeune, Stephanie | Lemaire, Mickaël | Leniger, Catherine | Leone, Marc | Leostic, Claudie | Lutomski, Chantal | Sailliol, Marianne | Martin, Claude-Denis | Matheron, Catherine | Mathieu, Jacques | Mendes, Anne-Christine | Mermillod-Blondin, Romain | Neuschwander, Arthur | Oueidat, Nathalie | Ould-Ahmed, Mehdi | Ozier, Yves | Paugam, Catherine | Peduzzi, Franck | Petermann, Alexandre | Peytel, Eric | Picou-Leblanc, Muriel | Pinero, David | Plaisance, Patrick | Raba, Michel | Ricard, Damien | Romanacce, Isabelle | Rossignol, Thomas | Rougelin-Clapasson, Christine | Saint-Paul, Amelie | Idri, Salim | Scotto, Christine | Senent, Laurence | Smadja, David | Tazarourte, Karim | Topin, Francois | Trichet, Catherine | Vocel, Alexia
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CCSD ; American Medical Association -
International audience.
IMPORTANCE Blood transfusion is a mainstay of therapy for trauma-induced coagulopathy, but the optimal modalities for plasma transfusion in the prehospital setting remain to be defined. OBJECTIVE To determine whether lyophilized plasma transfusion can reduce the incidence of trauma-induced coagulopathy compared with standard care consisting of normal saline infusion. DESIGN, SETTING, AND PARTICIPANTS This randomized clinical trial was performed at multiple centers in France involving prehospital medical teams. Participants included 150 adults with trauma who were at risk for hemorrhagic shock and associated coagulopathy between April 1, 2016, and
