CRISPR-Cas9 Targeting of Hepatitis B Virus Covalently Closed Circular DNA Generates Transcriptionally Active Episomal Variants

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Martinez, Maria Guadalupe | Combe, Emmanuel | Inchauspe, Aurore | Mangeot, Philippe Emmanuel | Delberghe, Elodie | Chapus, Fleur | Neveu, Gregory | Alam, Antoine | Carter, Kara | Testoni, Barbara | Zoulim, Fabien

Edité par CCSD ; American Society for Microbiology -

International audience. Hepatitis B virus infection can develop into chronic infection, cirrhosis, and hepatocellular carcinoma. Treatment of chronic hepatitis B requires novel approaches to directly target the viral minichromosome, which is responsible for the persistence of the disease.

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