Bronchopulmonary Dysplasia and Risk of Developmental Delay: An EPIPAGE-2 Cohort Study

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Tréluyer, Ludovic | Jarreau, Pierre-Henri | Marchand-Martin, Laetitia | Benhammou, Valerie | Nuytten, Alexandra | Berquin, Patrick | Marret, Stéphane | Pierrat, Véronique | Ancel, Pierre-Yves | Torchin, Héloïse

Edité par CCSD ; Karger -

International audience. Background: Overall and respiratory management of preterm children are constantly evolving, which might have changed both the pathophysiology and neurodevelopmental consequences of bronchopulmonary dysplasia (BPD). Objectives: The objective of this study is to determine whether the previously shown association between BPD and risk of developmental delay persists. Methods: The study population was children born before 32 weeks’ gestation from the French prospective cohort EPIPAGE-2. The exposure was BPD assessed at 36 weeks’ postmenstrual age. The main outcome was risk of developmental delay defined by an Age & Stages Questionnaires (ASQ) score below threshold at 24 months’ corrected age. Results: The analyzed population included 2,706 children. Among those with available ASQ score, 196/1,587 had BPD and 671/1,587 had an ASQ score below threshold. BPD was associated with an ASQ score below threshold (odds ratio 1.52, 95% confidence interval 1.11–2.08; p = 0.008). Conclusions: BPD was strongly associated with risk of developmental delay.

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