Syracuse

Urinary Marker Profiles in Heart Failure with Reduced Versus Preserved Ejection Fraction

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Streng, Koen, W | Hillege, Hans, L | ter Maaten, Jozine, M | van Veldhuisen, Dirk, J | Dickstein, Kenneth | Samani, Nilesh, J | Ng, Leong, L | Metra, Marco | Filippatos, Gerasimos, S | Ponikowski, Piotr | Zannad, Faiez | Anker, Stefan, D | van der Meer, Peter | Lang, Chim, C | Voors, Adriaan, A | Damman, Kevin

Edité par CCSD ; Springer -

International audience. Background: Recent data suggest different causes of renal dysfunction between heart failure with reduced (HFrEF) versus preserved ejection fraction (HFpEF). We therefore studied a wide range of urinary markers reflecting different nephron segments in heart failure patients.Methods: In 2070, in chronic heart failure patients, we measured several established and upcoming urinary markers reflecting different nephron segments.Results: Mean age was 70 ± 12 years, 74% was male and 81% (n = 1677) had HFrEF. Mean estimated glomerular filtration rate (eGFR) was lower in patients with HFpEF (56 ± 23 versus 63 ± 23 ml/min/1.73 m2, P = 0.001). Patients with HFpEF had significantly higher values of NGAL (58.1 [24.0-124.8] versus 28.1 [14.6-66.9] μg/gCr, P < 0.001) and KIM-1 (2.28 [1.49-4.37] versus 1.79 [0.85-3.49] μg/gCr, P = 0.001). These differences were more pronounced in patients with an eGFR > 60 ml/min/1.73m2.Conclusions: HFpEF patients showed more evidence of tubular damage and/or dysfunction compared with HFrEF patients, in particular when glomerular function was preserved.

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