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Mechanistic modeling of metastatic relapse in early breast cancer to investigate the biological impact of prognostic biomarkers

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Bigarré, Célestin | Bertucci, François | Finetti, Pascal | Macgrogan, Gaëtan | Muracciole, Xavier | Benzekry, Sébastien

Edité par CCSD ; Elsevier -

International audience. Estimating the risk of metastatic relapse is a major challenge to decide adjuvant treatment options in early-stage breast cancer (eBC). To date, distant metastasis-free survival (DMFS) analysis mainly relies on classical, agnostic, statistical models (e.g., Cox regression). Instead, we propose here to derive mechanistic models of DMFS.

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