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Identification of peptides interfering with the LRRK2/PP1 interaction

Archive ouverte | Dong, Chang Zhi | CCSD

International audience. Serine/threonine phosphatases are responsible for modulating the activities of the protein kinases implicated in the development of several pathologies. Here we identified by a PEP-scan appro...

Evaluation of Caspase-9b and PP2Acα2 as potential biomarkers for chronic lymphocytic leukemia

Archive ouverte | Domínguez-Berrocal, Leticia | CCSD

International audience. Background: Disruption of alternative splicing in apoptotic factors has been associated to chronic lymphocytic leukemia among other cancers and hematological malignancies. The proapoptotic pr...

Bifunctional Therapeutic Peptides for Targeting Malignant B Cells and Hepatocytes: Proof of Concept in Chronic Lymphocytic Leukemia

Archive ouverte | Simon-Gracia, Lorena | CCSD

International audience. Protein-protein interactions are well recognized as therapeutic targets and therefore interfering peptides (IP) that block these interactions are receiving increasing attention. Four differen...

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