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Interferon Receptor Trafficking and Signaling: Journey to the Cross Roads

Archive ouverte | Zanin, Natacha | CCSD

International audience. Like most plasma membrane proteins, type I interferon (IFN) receptor (IFNAR) traffics from the outer surface to the inner compartments of the cell. Long considered as a passive means to simpl...

EHD2 is a mechanotransducer connecting caveolae dynamics with gene transcription

Archive ouverte | Torrino, Stéphanie | CCSD

International audience. Caveolae are small invaginated pits that function as dynamic mechanosensors to buffer tension variations at the plasma membrane. Here we show that under mechanical stress, the EHD2 ATPase is ...

Coupling of melanocyte signaling and mechanics by caveolae is required for human skin pigmentation

Archive ouverte | Domingues, Lia | CCSD

International audience. Tissue homeostasis requires regulation of cell-cell communication, which relies on signaling molecules and cell contacts. In skin epidermis, keratinocytes secrete factors transduced by melano...

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