Afficher la couverture 'Lasp-1 (MLN 50) defines a new LIM protein subfamily characterized by the association of LIM and SH3 domains | Tomasetto, Catherine' en grand format
/5

0 avis

Lasp-1 (MLN 50) defines a new LIM protein subfamily characterized by the association of LIM and SH3 domains

Archive ouverte

Tomasetto, Catherine | Moog-Lutz, Christel | Régnier, Catherine H. | Schreiber, Valerie | Basset, Paul | Rio, Marie-Christine

Edité par CCSD ; Wiley -

MLN 50 was previously identified in a cDNA library of breast cancer metastasis. In this study, we show that MLN 50, which is expressed at a basal level in normal tissues, is overexpressed in 8% of human breast carcinomas most often together with c-erbB-2. MLN 50 cDNA encodes a putative protein of 261 residues, named Lasp-1 (LIM and SH3 protein) since it contains a LIM motif and a domain of Src homology region 3 (SH3) at the amino- and the C-terminal parts of the protein, respectively. Thus, Lasp-1 defines a new LIM protein subfamily.

Consulter en ligne

Suggestions

Du même auteur

Lasp-1, a novel type of actin-binding protein accumulating in cell membrane extensions

Archive ouverte | Schreiber, Valerie | CCSD

International audience. The Lasp-1 gene, which has been localized to the q12-q21 region of human chromosome 17, is amplified and overexpressed in human breast cancers. In addition to the previously reported LIM and ...

Comparative expression of the psoriasin (S100A7) and S100C genes in breast carcinoma and co-localization to human chromosome 1q21-q22

Archive ouverte | Moog-Lutz, Christel | CCSD

Using differential screening of a breast cancer cDNA library, we isolated a cDNA encoding the psoriasin (S100A7) protein, previously identified in psoriatic epidermis. In the present study, we demonstrate that the psoriasin gene i...

Presence of a new conserved domain in CART1, a novel member of the tumor necrosis factor receptor-associated protein family, which is expressed in breast carcinoma

Archive ouverte | Régnier, Catherine H. | CCSD

CART1, a novel human gene, encodes a putative protein exhibiting three main structural domains: first, a cysteine-rich domain located at the amino-terminal part of the protein, which corresponds to an unusual RING finger motif; se...

Chargement des enrichissements...