Suggestions

Du même auteur

NKp30 isoforms and NKp30 ligands are predictive biomarkers of response to imatinib mesylate in metastatic GIST patients

Archive ouverte | Rusakiewicz, Sylvie | CCSD

International audience. Despite effective targeted therapy acting on KIT and PDGFRA tyrosine kinases, gastrointestinal stromal tumors (GIST) escape treatment by acquiring mutations conveying resistance to imatinib m...

Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors

Archive ouverte | Routy, Bertrand | CCSD

International audience. Immune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 axis induce sustained clinical responses in a sizable minority of cancer patients. We found that primary resistance to ICIs can be...

Sustained Type I interferon signaling as a mechanism of resistance to PD-1 blockade

Archive ouverte | Jacquelot, Nicolas | CCSD

International audience. PD-1 blockade represents a major therapeutic avenue in anticancer immunotherapy. Delineating mechanisms of secondary resistance to this strategy is increasingly important. Here, we identified...

Chargement des enrichissements...