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Abnormal Sympathoadrenal Development and Systemic Hypotension in PHD3 − / − Mice

Archive ouverte | Bishop, Tammie | CCSD

International audience. ABSTRACT Cell culture studies have implicated the oxygen-sensitive hypoxia-inducible factor (HIF) prolyl hydroxylase PHD3 in the regulation of neuronal apoptosis. To better understand this fu...

Activation of the lectin DC-SIGN induces an immature dendritic cell phenotype triggering Rho-GTPase activity required for HIV-1 replication.

Archive ouverte | Hodges, Ashleigh | CCSD

International audience. DC-SIGN, a C-type lectin expressed on dendritic cells (DCs), can sequester human immunodeficiency virus (HIV) virions in multivesicular bodies. Here, using large-scale gene expression profili...

A Ribosomopathy Reveals Decoding Defective Ribosomes Driving Human Dysmorphism

Archive ouverte | Paolini, Nahuel | CCSD

International audience. Ribosomal protein (RP) gene mutations, mostly associated with inherited or acquired bone marrow failure, are believed to drive disease by slowing the rate of protein synthesis. Here de novo m...

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