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The inactivation of Arx in pancreatic α-cells triggers their neogenesis and conversion into functional β-like cells.

Archive ouverte | Courtney, Monica | CCSD

International audience. Recently, it was demonstrated that pancreatic new-born glucagon-producing cells can regenerate and convert into insulin-producing β-like cells through the ectopic expression of a single gene,...

Adult Duct-Lining Cells Can Reprogram into β-like Cells Able to Counter Repeated Cycles of Toxin-Induced Diabetes.

Archive ouverte | Al-Hasani, Keith | CCSD

International audience. It was recently demonstrated that embryonic glucagon-producing cells in the pancreas can regenerate and convert into insulin-producing β-like cells through the constitutive/ectopic expression...

Gastrin: a distinct fate of neurogenin3 positive progenitor cells in the embryonic pancreas.

Archive ouverte | Suissa, Yaron | CCSD

International audience. Neurogenin3(+) (Ngn3(+)) progenitor cells in the developing pancreas give rise to five endocrine cell types secreting insulin, glucagon, somatostatin, pancreatic polypeptide and ghrelin. Gast...

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