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Divergent function of polycystin 1 and polycystin 2 in cell size regulation

Archive ouverte | Viau, Amandine | CCSD

International audience. Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations in PKD1 or PKD2, the genes encoding polycystin 1 (PC1) and polycystin 2 (PC2), respectively. PC1 and PC2 localize t...

Cilia‐localized LKB 1 regulates chemokine signaling, macrophage recruitment, and tissue homeostasis in the kidney

Archive ouverte | Viau, Amandine | CCSD

International audience. Polycystic kidney disease (PKD) and other renal ciliopathies are characterized by cysts, inflammation, and fibrosis. Cilia function as signaling centers, but a molecular link to inflammation ...

Targeting mTOR Signaling Can Prevent the Progression of FSGS

Archive ouverte | Zschiedrich, Stefan | CCSD

International audience. Mammalian target of rapamycin (mTOR) signaling is involved in a variety of kidney diseases. Clinical trials administering mTOR inhibitors to patients with FSGS, a prototypic podocyte disease,...

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