The effect of the 7R allele on the DRD4 risk tolerance locus is independent of background risk in Senegalese fishermen

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Clochard, Gwen-Jiro | Mbengue, Aby | Mettling, Clément | Diouf, Birane | Faurie, Charlotte | Sene, Omar | Chancerel, Emilie | Guichoux, Erwan | Hollard, Guillaume | Raymond, Michel | Willinger, Marc

Edité par CCSD ; Nature Publishing Group -

International audience. It has been shown that living in risky environments, as well as having a risky occupation, can moderate risk-tolerance. Despitethe involvement of dopamine in the expectation of reward described by neurobiologists, a GWAS study was not able todemonstrate a genetic contribution of genes involved in the dopaminergic pathway in risk attitudes and gene candidate studiesgave contrasting results. We test the possibility that a genetic effect of the DRD4-7R allele in risk-taking behavior could bemodulated by environmental factors. We show that the increase in risk-tolerance due to the 7R allele is independent of theenvironmental risk in two populations in Northern Senegal, one of which is exposed to a very high risk due to dangerous fishing.

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