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A novel role for myeloid endothelin-B receptors in hypertension

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Czopek, Alicja | Moorhouse, Rebecca | Guyonnet, Léa | Farrah, Tariq | Lenoir, Olivia | Owen, Elizabeth | van Bragt, Job | Costello, Hannah, M | Menolascina, Filippo | Baudrie, Véronique | Webb, David, J | Kluth, David, C | Bailey, Matthew, A | Tharaux, Pierre-Louis | Dhaun, Neeraj

Edité par CCSD ; Oxford University Press (OUP) -

International audience. Hypertension is common. Recent data suggest that macrophages (M/) contribute to, and protect from, hypertension. Endothelin-1 (ET-1) is the most potent endogenous vasoconstrictor with additional pro-inflammatory properties. We investigated the role of the ET system in experimental and clinical hypertension by modifying M/ number and phenotype.

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