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Cytosolic PCNA interacts with p47phox and controls NADPH oxidase NOX2 activation in neutrophils

Archive ouverte | Ohayon, Delphine | CCSD

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Cytosolic PCNA interacts with p47phox and controls NADPH oxidase NOX2 activation in neutrophils

Archive ouverte | Ohayon, Delphine | CCSD

Neutrophils produce high levels of reactive oxygen species (ROS) by NADPH oxidase that are crucial for host defense but can lead to tissue injury when produced in excess. We previously described that proliferating cell nuclear ant...

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Archive ouverte | Everts-Graber, Judith | CCSD

International audience. Granulomatosis with polyangiitis (GPA) is an autoimmune vasculitis associated with anti-neutrophil-cytoplasmic antibodies (ANCA) against proteinase 3 leading to kidney damage. Neutrophils fro...

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