Afficher la couverture 'Golgipathies reveal the critical role of the sorting machinery in brain and skeletal development | El Ghouzzi, Vincent' en grand format
/5

0 avis

Golgipathies reveal the critical role of the sorting machinery in brain and skeletal development

Archive ouverte

El Ghouzzi, Vincent | Boncompain, Gaelle

Edité par CCSD ; Nature Publishing Group -

International audience. Association genetic studies and genome-scale CRISPR screens have recently identified ARF3 and TMEM251/LYSET/GCAF as Golgi-resident factors essential to brain and skeletal development. Here we discuss how even though the consequences of mutations in these genes affect endosomal and lysosomal compartments, the problem originates in the Golgi complex and may involve either the identity of the carrier vesicles or that of cargo molecules. 1234567890():,; 1234567890():,;

Suggestions

Du même auteur

Golgi Dysfunctions in Ciliopathies

Archive ouverte | Masson, Justine | CCSD

International audience. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY

Molecular and cellular bases of syndromic craniosynostoses

Archive ouverte | Bonaventure, Jacky | CCSD

International audience. Premature fusion of cranial sutures underlies the clinical condition of 'craniosynostosis', a common human disorder that occurs in both nonsyndromic and syndromic forms. The subgroup of syndr...

Twist haploinsufficiency in Saethre-Chotzen syndrome induces calvarial osteoblast apoptosis due to increased TNFalpha expression and caspase-2 activation

Archive ouverte | Yousfi, Malika | CCSD

International audience. Saethre-Chotzen syndrome (SCS) is a human autosomal dominant disorder characterized by premature fusion of cranial sutures caused by mutations of the Twist gene encoding a basic helix-loop-he...

Chargement des enrichissements...