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Somatic mutations in ATP1A1 and ATP2B3 lead to aldosterone-producing adenomas and secondary hypertension

Archive ouverte | Beuschlein, Felix | CCSD

International audience. Primary aldosteronism is the most prevalent form of secondary hypertension. To explore molecular mechanisms of autonomous aldosterone secretion, we performed exome sequencing of aldosterone-p...

Aldosterone-producing adenoma formation in the adrenal cortex involves expression of stem/progenitor cell markers.

Archive ouverte | Boulkroun, Sheerazed | CCSD

International audience. Aldosterone producing adenoma (APA) is the most common form of surgically curable hypertension. To further understand mechanisms involved in APA formation, we investigated the expression of m...

Genetic, Cellular, and Molecular Heterogeneity in Adrenals With Aldosterone-Producing Adenoma

Archive ouverte | de Sousa, Kelly | CCSD

International audience. Aldosterone-producing adenoma (APA) cause primary aldosteronism—the most frequent form of secondary hypertension. Somatic mutations in genes coding for ion channels and ATPases are found in A...

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