Localization of contractile wave nucleation sites as an emerging phenomenon of stochastic myogenic gut motility

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Chevalier, Nicolas R.

Edité par CCSD ; Frontiers media -

International audience. In their recent article, Shikaya et al. (2022) reported on the existence of preferential sites of nucleation of contractile waves along the chicken embryonic day 12 midgut, termed sites of “origin of peristaltic waves” (OPW). Histological analysis by the authors did not reveal any peculiarities of these sites compared to other locations along the gut. Applying tetrodotoxin or ablating neural crest cells did not suppress the OPWs, but led to a shift in the position of the OPWs along the gut tract. From these observations, the authors suggested that the enteric nervous system may be involved in the motility at earlier stages than previously reported (E16) (Chevalier et al., 2019). Here, I show by simulation that OPWs can emerge spontaneously in smooth muscle tissue that has a high probability of spontaneous depolarization and an associated refractory period, without need for pacemaker or neurogenic activity. The simulations additionally demonstrates that pacemaking by Interstitial Cells of Cajal requires a developmental decrease of the spontaneous depolarization probability of the smooth muscle syncytium.

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