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Structural basis of rapid actin dynamics in the evolutionarily divergent Leishmania parasite

Archive ouverte | Kotila, Tommi | CCSD

International audience. Abstract Actin polymerization generates forces for cellular processes throughout the eukaryotic kingdom, but our understanding of the ‘ancient’ actin turnover machineries is limited. We show ...

Recycling of the actin monomer pool limits the lifetime of network turnover

Archive ouverte | Colin, Alexandra | CCSD

International audience. Intracellular organization is largely mediated by actin turnover. Cellular actin networks continuously assemble and disassemble, while maintaining their overall appearance. This behavior, cal...

Tropomyosin isoforms specify functionally distinct actin filament populations in vitro

Archive ouverte | Gateva, Gergana | CCSD

Actin filaments assemble into a variety of networks to provide force for diverse cellular processes [1]. Tropomyosins are coiled-coil dimers that form head-to-tail polymers along actin filaments and regulate interactions of other ...

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