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Induction of resident memory T cells enhances the efficacy of cancer vaccine

Archive ouverte | Nizard, Mevyn | CCSD

International audience. Abstract Tissue-resident memory T cells (Trm) represent a new subset of long-lived memory T cells that remain in tissue and do not recirculate. Although they are considered as early immune ef...

Mucosal Imprinting of Vaccine-Induced CD8(+) T Cells Is Crucial to Inhibit the Growth of Mucosal Tumors

Archive ouverte | Sandoval, Federico | CCSD

International audience. Although many human cancers are located in mucosal sites, most cancer vaccines are tested against subcutaneous tumors in preclinical models. We therefore wondered whether mucosa-specific homi...

CXCR6 deficiency impairs cancer vaccine efficacy and CD8 + resident memory T-cell recruitment in head and neck and lung tumors

Archive ouverte | Karaki, Soumaya | CCSD

International audience. Background Resident memory T lymphocytes (TRM) are located in tissues and play an important role in immunosurveillance against tumors. The presence of TRM prior to treatment or their inductio...

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