Interim 2019/20 Influenza Vaccine Effectiveness: Six European Studies, September 2019 to January 2020
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Rose, Angela | Kissling, Esther | Emborg, Hanne-Dorthe | Larrauri, Amparo | Mcmenamin, Jim | Pozo, Francisco | Trebbien, Ramona | Mazagatos, Clara | Whitaker, Heather | Valenciano, Marta | Lopez, Daniel Thomas | Krause, Tyra Grove | Falchi, France Alessandra | Masse, Shirley | Vilcu, Ana-Maria | Souty, Cécile | Blanchon, Thierry | Launay, Titouan | Werf, Sylvie van Der | Enouf, Vincent | Behillil, Sylvie | Lina, Bruno | Valette, Martine | Moren, Alain | Penttinen, Pasi | Buda, Silke | Preuss, Ute | Tolksdorf, Kristin | Biere, Barbara | Duerrwald, Ralf | Smallfield, Maria | Wedde, Robert Koch Marianne | Domegan, Lisa | Fiegenbaum, Rachel | O’donnell, Joan | Joyce, Michael | Levis, Olga | Collins, Claire | Bennett, Charlene | Moran, Joanne | Tuite, Grainne | Connell, Jeff | Gascun, Cillian De | Meijer, Adam | Lange, Marit De | Brink, Sharon van Den | Dijkstra, Frederika | Hooiveld, Mariette | Rodrigues, Ana Paula | Machado, Ausenda | Nunes, Baltazar | Kislaya, Irina | Gomez, Verónica | Costa, Inês | Conde, Patrícia | Cristóvão, Paula | Pechirra, Pedro | Guiomar, Raquel | Lazar, Mihaela | Cherciu, Carmen Maria | Mihai, Maria Elena | Duca, Elena | Luca, Mihaela Catalina | Gradinaru, Maria | Loghin, Izabela | Manciuc, Carmen | Tardei, Grațiela | Nica, Maria | Florescu, Simin-Aysel | Ceausu, Emanoil | Casas, Inmaculada | Comas, Luis García | Marisquerena, María Esther Insua | Galán, Juan Carlos | Folgueira, Mª Dolores | Rubio, Carmen Quiñones | Ochoa, Eva Martinez | Blasco, Miriam | Duran, Jaume Gimenez | Vanrell, Juana Maria | Reina, Jordi | Castrillejo, Daniel | Delgado, Concha | Oliva, Jesus | Latorre-Millán, Miriam | Milagro, Ana María | Rezusta, Antonio | Sierra, M. Amelia Fernández | Ruiz, Mercedes Pérez | Rodríguez, María del Mar | Castilla, Jesús | Cenoz, Manuel García | Casado, Itziar | Martínez-Baz, Iván | Ibañez, Carlos Gómez | Iriarte, Nerea | Navascués, Ana | Portillo, M Eugenia | Ezpeleta, Carmen | Wiman, Åsa | Enkirch, Theresa | Marques, Diogo F.P. | Gunson, Rory | Robertson, Chris | Cottrell, Simon | Moore, Catherine | O’doherty, Mark | Johnston, Jillian | Mccaughey, Conall | Lusignan, Simon De | Yonova, Ivelina | Tripathy, Manasa | Byford, Rachel | Ferreria, Filipa | Lopezbernal, Jamie | Pebody, Richard | Sinnathamby, Mary | Andrews, Nick | Ellis, Joanna | Sebastianpillai, Praveen | Zambon, Maria
Edité par
CCSD ; European Centre for Disease Prevention and Control -
International audience.
Background Influenza A(H1N1)pdm09, A(H3N2) and B viruses were co-circulating in Europe between September 2019 and January 2020. Aim To provide interim 2019/20 influenza vaccine effectiveness (VE) estimates from six European studies, covering 10 countries and both primary care and hospital settings. Methods All studies used the test-negative design, although there were some differences in other study characteristics, e.g. patient selection, data sources, case definitions and included age groups. Overall and influenza (sub)type-specific VE was estimated for each study using logistic regression adjusted for potential confounders. Results There were 31,537 patients recruited across the six studies, of which 5,300 (17%) were cases with 5,310 infections. Most of these (4,466; 84%) were influenza A. The VE point estimates for all ages were 29% to 61% against any influenza in the primary care setting and 35% to 60% in hospitalised older adults (aged 65 years and over). The VE point estimates against A(H1N1)pdm09 (all ages, both settings) was 48% to 75%, and against A(H3N2) ranged from -58% to 57% (primary care) and -16% to 60% (hospital). Against influenza B, VE for all ages was 62% to 83% (primary care only). Conclusions Influenza vaccination is of continued benefit during the ongoing 2019/20 influenza season. Robust end-of-season VE estimates and genetic virus characterisation results may help understand the variability in influenza (sub)type-specific results across studies.
