Context-dependent function of TSLP and IL-1β in skin allergic sensitization and atopic march

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Segaud, Justine | Yao, Wenjin | Marschall, Pierre | Daubeuf, François | Lehalle, Christine | German, Beatriz | Meyer, Pierre | Hener, Pierre | Hugel, Cécile | Flatter, Eric | Guivarch, Marine | Clauss, Laetitia | Martin, Stefan | Oulad-Abdelghani, Mustapha | Li, Mei

Edité par CCSD ; Nature Publishing Group -

International audience. Abstract Atopic diseases, including atopic dermatitis (AD) and asthma, affect a large proportion of the population, with increasing prevalence worldwide. AD often precedes the development of asthma, known as the atopic march. Allergen sensitization developed through the barrier-defective skin of AD has been recognized to be a critical step leading to asthma, in which thymic stromal lymphopoietin (TSLP) was previously shown to be critical. In this study, using a laser-assistant microporation system to disrupt targeted skin layers for generating micropores at a precise anatomic depth of mouse skin, we model allergen exposure superficially or deeply in the skin, leading to epicutaneous sensitization or dermacutaneous sensitization that is associated with a different cytokine microenvironment. Our work shows a differential requirement for TSLP in these two contexts, and identifies an important function for IL-1β, which is independent of TSLP, in promoting allergen sensitization and subsequent allergic asthma.

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