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Determining probabilities of HIV-1 bNAb development in healthy and chronically infected individuals

Archive ouverte | Kreer, Christoph | CCSD

Abstract HIV-1 broadly neutralizing antibodies (bNAbs) are able to suppress viremia and prevent infection. Their induction by vaccination is therefore a major goal. However, in contrast to antibodies that neutralize other pathogen...

Probabilities of developing HIV-1 bNAb sequence features in uninfected and chronically infected individuals

Archive ouverte | Kreer, Christoph | CCSD

International audience. HIV-1 broadly neutralizing antibodies (bNAbs) are able to suppress viremia and prevent infection. Their induction by vaccination is therefore a major goal. However, in contrast to antibodies ...

Local and Global Variability in Developing Human T-Cell Repertoires

Archive ouverte | Isacchini, Giulio | CCSD

International audience. The adaptive immune response relies on T cells that combine phenotypic specialization with diversity of T cell receptors (TCRs) to recognize a wide range of pathogens. TCRs are acquired and s...

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