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Interaction between Hormone-Sensitive Lipase and ChREBP in Fat Cells Controls Insulin Sensitivity

Archive ouverte | Morigny, Pauline | CCSD

International audience. Impaired adipose tissue insulin signalling is a critical feature of insulin resistance. Here we identify a pathway linking the lipolytic enzyme hormone-sensitive lipase (HSL) to insulin actio...

Cold-induced thermogenesis requires neutral-lipase-mediated intracellular lipolysis in brown adipocytes

Archive ouverte | Mouisel, Etienne | CCSD

International audience. Long-chain fatty acids (FAs) are the major substrates fueling brown adipose tissue (BAT) thermogenesis. Investigation of mouse models has previously called into question the contribution of b...

Partial inhibition of adipose tissue lipolysis improves glucose metabolism and insulin sensitivity without alteration of fat mass.

Archive ouverte | Girousse, Amandine | CCSD

International audience. When energy is needed, white adipose tissue (WAT) provides fatty acids (FAs) for use in peripheral tissues via stimulation of fat cell lipolysis. FAs have been postulated to play a critical r...

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