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The Dependence Receptor UNC5H2/B Triggers Apoptosis via PP2A-Mediated Dephosphorylation of DAP Kinase

Archive ouverte | Guenebeaud, Céline | CCSD

International audience. The UNC5H dependence receptors promote apoptosis in the absence of their ligand, netrin-1, and this is important for neuronal and vascular development and for limitation of cancer progression...

Inhibition of endothelial cell apoptosis by Netrin-1 during angiogenesis

Archive ouverte | Castets, Marie | CCSD

International audience. Netrin-1 was recently proposed to play an important role in embryonic and pathological angiogenesis. However, data reported led to the apparently contradictory conclusions that netrin-1 is ei...

Interfering with multimerization of netrin-1 receptors triggers tumor cell death.

Archive ouverte | Mille, Frédéric | CCSD

International audience. Netrin-1 was recently proposed to control tumorigenesis by inhibiting apoptosis induced by the dependence receptors DCC (Deleted in colorectal cancer) and UNC5H. Although the loss of these de...

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