Suggestions

Du même auteur

PatchSearch: a web server for off-target protein identification

Archive ouverte | Rey, Julien | CCSD

International audience. Abstract The large number of proteins found in the human body implies that a drug may interact with many proteins, called off-target proteins, besides its intended target. The PatchSearch web...

Molecular Rescue of Dyrk1A Overexpression Alterations in Mice with Fontup (R) Dietary Supplement: Role of Green Tea Catechins

Archive ouverte | Gu, Yuchen | CCSD

International audience. Epigallocatechin gallate (EGCG) is an inhibitor of DYRK1A, a serine/threonine kinase considered to be a major contributor of cognitive dysfunctions in Down syndrome (DS). Two clinical trials ...

Exploring the Structural Rearrangements of the Human Insulin-Degrading Enzyme through Molecular Dynamics Simulations

Archive ouverte | Ghoula, Mariem | CCSD

International audience. Insulin-degrading enzyme (IDE) is a ubiquitously expressed metallopeptidase that degrades insulin and a large panel of amyloidogenic peptides. IDE is thought to be a potential therapeutic tar...

Chargement des enrichissements...