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Impaired excitation-contraction coupling in muscle fibres from the dynamin2 R465W mouse model of centronuclear myopathy

Archive ouverte | Kutchukian, Candice | CCSD

International audience. Key points: Dynamin 2 is a ubiquitously expressed protein involved in membrane trafficking processes. Mutations in the gene encoding dynamin 2 are responsible for a congenital myopathy associ...

Ca2+-induced sarcoplasmic reticulum Ca2+ release in myotubularin-deficient muscle fibers

Archive ouverte | Kutchukian, Candice | CCSD

International audience. Skeletal muscle deficiency in the 3-phosphoinositide (PtdInsP) phosphatase myotubularin (MTM1) causes myotubular myopathy which is associated with severe depression of voltage-activated sarco...

Detection of Ca2+ transients near ryanodine receptors by targeting fluorescent Ca2+ sensors to the triad

Archive ouverte | Sanchez, Colline | CCSD

International audience. In intact muscle fibers, functional properties of ryanodine receptor (RYR)-mediated sarcoplasmic reticulum (SR) Ca 2+ release triggered by activation of the voltage sensor Ca V 1.1 have so fa...

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