Mannobioside biomimetics that trigger DC-SIGN binding selectivity

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Mannobioside biomimetics that trigger DC-SIGN binding selectivity

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Edité par CCSD ; Royal Society of Chemistry -

International audience. Selective DC-SIGN targeting vs. langerin might lead to anti-infective agents, given their counteracting effects upon infection by some pathogens. Here we show that multivalent sp2-iminosugar-containing mannobioside analogs can achieve total DC-SIGN selectivity by levering the canonic binding mode towards high-mannose oligosaccharide ligands, behaving as factual biomimics

Langue: en

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