Interactions Between Severe Acute Respiratory Syndrome Coronavirus 2 Replication and Major Respiratory Viruses in Human Nasal Epithelium

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Pizzorno, Andrés | Padey, Blandine | Dulière, Victoria | Mouton, William | Oliva, Justine | Laurent, Emilie | Milesi, Cedrine | Lina, Bruno | Traversier, Aurelien | Julien, Thomas | Trouillet-Assant, Sophie | Rosa-Calatrava, Manuel | Terrier, Olivier

Edité par CCSD ; Oxford University Press -

International audience. Abstract The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), along with extensive nonpharmacological interventions, have profoundly altered the epidemiology of major respiratory viruses. Some studies have described virus-virus interactions, particularly manifested by viral interference mechanisms at different scales. However, our knowledge of the interactions between SARS-CoV-2 and other respiratory viruses remains incomplete. Here, we studied the interactions between SARS-CoV-2 and several respiratory viruses (influenza, respiratory syncytial virus, human metapneumovirus, and human rhinovirus) in a reconstituted human epithelial airway model, exploring different scenarios affecting the sequence and timing of coinfections. We show that the virus type and sequence of infections are key factors in virus-virus interactions, the primary infection having a determinant role in the immune response to the secondary infection.

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