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Hyperglycemia triggers RyR2-dependent alterations of mitochondrial calcium homeostasis in response to cardiac ischemia-reperfusion: Key role of DRP1 activation

Archive ouverte | Dubois, Mathilde | CCSD

International audience. Hyperglycemia increases the heart sensitivity to ischemia-reperfusion (IR), but the underlying cellular mechanisms remain unclear. Mitochondrial dynamics (the processes that govern mitochondr...

Exercise training may reduce fragmented mitochondria in the ischemic-reperfused heart through DRP1

Archive ouverte | Dubois, Mathilde | CCSD

International audience. Mitochondrial fission is a key trigger of cardiac ischemia-reperfusion injuries (IR). Exercise training is an efficient cardioprotective strategy, but its impact on mitochondrial fragmentatio...

Increased protein S-nitrosylation in mitochondria: a key mechanism of exercise-induced cardioprotection

Archive ouverte | Boulghobra, Doria | CCSD

International audience. Endothelial nitric oxide synthase (eNOS) activation in the heart plays a key role in exercise-induced cardioprotection during ischemia-reperfusion, but the underlying mechanisms remain unknow...

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