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Loss of prion protein control of glucose metabolism promotes neurodegeneration in model of prion diseases

Archive ouverte | Arnould, Hélène | CCSD

International audience. Corruption of cellular prion protein (PrP C ) function(s) at the plasma membrane of neurons is at the root of prion diseases, such as Creutzfeldt-Jakob disease and its variant in humans, and ...

Double-Edge Sword of Sustained ROCK Activation in Prion Diseases through Neuritogenesis Defects and Prion Accumulation

Archive ouverte | Alleaume-Butaux, Aurélie | CCSD

International audience. In prion diseases, synapse dysfunction, axon retraction and loss of neuronal polarity precede neuronal death. The mechanisms driving such polarization defects, however, remain unclear. Here, ...

Production of seedable Amyloid-β peptides in model of prion diseases upon PrPSc-induced PDK1 overactivation

Archive ouverte | Ezpeleta, Juliette | CCSD

International audience

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