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Chromosome-scale assembly of the yellow mealworm genome
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Edité par CCSD ; F1000 Research Limited on behalf of the European Commission -
International audience. Background: The yellow mealworm beetle, $Tenebrio\ molitor$ , is a promising alternative protein source for animal and human nutrition and its farming involves relatively low environmental costs. For these reasons, its industrial scale production started this century. However, to optimize and breed sustainable new $T.\ molitor$ lines, the access to its genome remains essential. Methods: By combining Oxford Nanopore and Illumina Hi-C data, we constructed a high-quality chromosome-scale assembly of $T.\ molitor$ . Then, we combined RNA-seq data and available coleoptera proteomes for gene prediction with GMOVE. Results: We produced a high-quality genome with a N50 = 21.9Mb with a completeness of 99.5% and predicted 21,435 genes with a median size of 1,780 bp. Gene orthology between $T.\ molitor$ and $Tribolium\ castaneum$ showed a highly conserved synteny between the two coleoptera and paralogs search revealed an expansion of histones in the $T.\ molitor$ genome. Conclusions: The present genome will greatly help fundamental and applied research such as genetic breeding and will contribute to the sustainable production of the yellow mealworm.
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