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Metallic trans-(N-Heterocyclic Carbene)-Amine-Platinum Complexes and Uses Thereof for Treating Cancer

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Betzer, Jean-François | Marinetti, Angela | Bombard, Sophie | Ghosh, Deepanjan | Jia, Tao

Edité par CCSD -

The present invention concerns new bimetallic trans-(N-Heterocyclic Carbene)-amine-Pt(II) complexes, and uses thereof for treating cancer in particular in combination with radiotherapy or in combination with radiotherapy and any anticancer drug. The present invention also concerns monometallic (Amine)Platinum(II) N-Heterocyclic Carbene complexes for treating cancer in particular in combination with radiotherapy or in combination with radiotherapy and any anticancer drug. Combined therapy is often used in clinic due to the fact that some drugs can induce synergistic effects when used at their subtoxic concentrations, thereby reducing their secondary toxic effects. Radiotherapy, is one of the most used modality in clinic (in 50% of the cases) but suffers some limitations namely radioresistance of tumor cells and reactions in normal tissue around the tumor.

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