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Tamoxifen Accelerates Endothelial Healing by Targeting ERα in Smooth Muscle Cells

Archive ouverte | Zahreddine, Rana | CCSD

International audience. RATIONALE: Tamoxifen prevents the recurrence of breast cancer and is also beneficial against bone demineralization and arterial diseases. It acts as an ER (estrogen receptor) α antagonist in ...

The different natural estrogens promote endothelial healing through distinct cell targets

Archive ouverte | Davezac, Morgane | CCSD

International audience. The main estrogen, 17β-estradiol (E2), exerts several beneficial vascular actions through estrogen receptor α (ERα) in endothelial cells. However, the impact of other natural estrogens such a...

Estrogen Receptor and Vascular Aging

Archive ouverte | Davezac, Morgane | CCSD

International audience. Cardiovascular diseases remain an age-related pathology in both men and women. These pathologies are 3-fold more frequent in men than in women before menopause, although this difference progr...

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