Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease
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Zanoni, Paolo | Khetarpal, Sumeet | Larach, Daniel | Hancock-Cerutti, William | Millar, John | Cuchel, Marina | Derohannessian, Stephanie | Kontush, Anatol | Surendran, Praveen | Saleheen, Danish | Trompet, Stella | Jukema, J. Wouter | de Craen, Anton | Deloukas, Panos | Sattar, Naveed | Ford, Ian | Packard, Chris | Majumder, Abdullah Al Shafi | Alam, Dewan | Di Angelantonio, Emanuele | Abecasis, Goncalo | Chowdhury, Rajiv | Erdmann, Jeanette | Nordestgaard, Børge | Nielsen, Sune | Tybjærg-Hansen, Anne | Schmidt, Ruth Frikke | Kuulasmaa, Kari | Liu, Dajiang | Perola, Markus | Blankenberg, Stefan | Salomaa, Veikko | Männistö, Satu | Amouyel, Philippe | Arveiler, Dominique | Ferrieres, Jean | Müller-Nurasyid, Martina | Ferrario, Marco | Kee, Frank | Willer, Cristen | Samani, Nilesh | Schunkert, Heribert | Butterworth, Adam | Howson, Joanna | Peloso, Gina | Stitziel, Nathan | Danesh, John | Kathiresan, Sekar | Rader, Daniel | Watson, Sarah | Schmidt, Ellen | Sengupta, Sebanti | Gustafsson, Stefan | Kanoni, Stavroula | Ganna, Andrea | Chen, Jin | Buchkovich, Martin | Mora, Samia | Beckmann, Jacques | Bragg-Gresham, Jennifer | Chang, Hsing-Yi | Demirkan, Ayşe | den Hertog, Heleen | Do, Ron | Donnelly, Louise | Ehret, Georg | Esko, Tõnu | Feitosa, Mary | Ferreira, Teresa | Fischer, Krista | Fontanillas, Pierre | Fraser, Ross | Freitag, Daniel | Gurdasani, Deepti | Heikkilä, Kauko | Hyppönen, Elina | Isaacs, Aaron | Jackson, Anne | Johansson, Åsa | Johnson, Toby | Kaakinen, Marika | Kettunen, Johannes | Kleber, Marcus | Li, Xiaohui | Luan, Jian’an | Lyytikäinen, Leo-Pekka | Magnusson, Patrik | Mangino, Massimo | Mihailov, Evelin | Montasser, May | Nolte, Ilja | O’connell, Jeffrey | Palmer, Cameron | Petersen, Ann-Kristin | Sanna, Serena | Saxena, Richa | Service, Susan | Shah, Sonia | Shungin, Dmitry | Sidore, Carlo | Song, Ci | Strawbridge, Rona | Surakka, Ida | Tanaka, Toshiko | Teslovich, Tanya | Thorleifsson, Gudmar | van den Herik, Evita | Voight, Benjamin | Volcik, Kelly | Waite, Lindsay | Wong, Andrew | Wu, Ying | Zhang, Weihua | Absher, Devin | Asiki, Gershim | Barroso, Inês | Been, Latonya | Bolton, Jennifer | Bonnycastle, Lori | Brambilla, Paolo | Burnett, Mary | Cesana, Giancarlo | Dimitriou, Maria | Doney, Alex | Döring, Angela | Elliott, Paul | Epstein, Stephen | Eyjolfsson, Gudmundur Ingi | Gigante, Bruna | Goodarzi, Mark | Grallert, Harald | Gravito, Martha | Groves, Christopher | Hallmans, Göran | Hartikainen, Anna-Liisa | Hayward, Caroline | Hernandez, Dena | Hicks, Andrew | Holm, Hilma | Hung, Yi-Jen | Illig, Thomas | Jones, Michelle | Kaleebu, Pontiano | Kastelein, John | Khaw, Kay-Tee | Kim, Eric | Klopp, Norman | Komulainen, Pirjo | Kumari, Meena | Langenberg, Claudia | Lehtimäki, Terho | Lin, Shih-Yi | Lindström, Jaana | Loos, Ruth | Mach, François | Mcardle, Wendy | Meisinger, Christa | Mitchell, Braxton | Müller, Gabrielle | Nagaraja, Ramaiah | Narisu, Narisu | Nieminen, Tuomo | Nsubuga, Rebecca | Olafsson, Isleifur | Ong, Ken | Palotie, Aarno | Papamarkou, Theodore | Pomilla, Cristina | Pouta, Anneli | Reilly, Muredach | Ridker, Paul | Rivadeneira, Fernando | Rudan, Igor | Ruokonen, Aimo | Scharnagl, Hubert | Seeley, Janet | Silander, Kaisa | Stancáková, Alena | Stirrups, Kathleen | Swift, Amy | Tiret, Laurence | Uitterlinden, Andre | van Pelt, L. | Vedantam, Sailaja | Wainwright, Nicholas | Wijmenga, Cisca | Wild, Sarah | Willemsen, Gonneke | Wilsgaard, Tom | Wilson, James | Young, Elizabeth | Zhao, Jing Hua | Adair, Linda | Assimes, Themistocles | Bandinelli, Stefania | Bennett, Franklyn | Bochud, Murielle | Boehm, Bernhard | Boomsma, Dorret | Borecki, Ingrid | Bornstein, Stefan | Bovet, Pascal | Burnier, Michel | Campbell, Harry | Chakravarti, Aravinda | Chambers, John | Chen, Yii-Der Ida | Collins, Francis | Cooper, Richard | Dedoussis, George | de Faire, Ulf | Feranil, Alan | Ferrucci, Luigi | Freimer, Nelson | Gieger, Christian | Groop, Leif | Gudnason, Vilmundur | Gyllensten, Ulf | Hamsten, Anders | Harris, Tamara | Hingorani, Aroon | Hirschhorn, Joel | Hofman, Albert | Hovingh, G. 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A scavenger that protects the heart Coronary heart disease is a tale of two forms of plasma cholesterol. In contrast to the well-established effects of “bad” cholesterol (LDL-C), the role of “good” cholesterol (HDL-C) is mysterious. Elevated HDL-C correlates with a lower risk of heart disease, yet drugs that raise HDL-C levels do not reduce risk. Zanoni et al. found that some people with exceptionally high levels of HDL-C carry a rare sequence variant in the gene encoding the major HDL-C receptor, scavenger receptor BI. This variant destroys the receptor's ability to take up HDL-C. Interestingly, people with this variant have a higher risk of heart disease despite having high levels of HDL-C. Science , this issue p. 1166
