Efficient detection of interchromosomal rearrangements in Holstein bulls using large SNP datasets

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Jourdain, J | Pinton, A | Barasc, H | Barbat, A | Hozé, C | Philippe, M | Boichard, Didier | Capitan, A

Edité par CCSD -

International audience. Chromosomal structural rearrangements are the cause of reproductive problems. They can be transmitted between generations by progeny carrying a balanced translocation. Detection and elimination of carrier bulls and their carrier progeny is desirable to increase on-farm conception rates. In this paper, we propose to detect these chromosomal abnormalities based on a significant association disequilibrium between markers of different chromosomes in the progeny of a bull. This approach applied to 2445 Holstein artificial insemination (AI) sire families resulted in the detection of 10 candidate rearrangements (0.41% of bulls). Most of the suspected bulls had low conception rates (relative loss of 29-65% compared to breed average). While historically, translocation studies in cattle focused on targeted cases, our method can be used routinely to detect chromosomal rearrangements based on SNP genotypes available for genomic evaluation.

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